The research of the developing model to take care HIV infection and AIDS patients by using Buddhism in Isan is beneficial to understanding the cultural, religious customs of Isan communities in using Buddhism in tending to HIV and AIDS patients. The belief of Buddhism in Northeast Thailand has a direct impact on the physical, mental, spiritual, social and economical aspects of everyone in Isan. Buddhist philosophy has successfully been applied to the treatment and caring of HIV patients, enabling them to live a quality life full of meaning and hope. Buddhism has enabled HIV patients to adjust themselves to the illness. This was very different from the past where they were confused and medical treatments were without direction. Modern medical treatments supplemented with alternatives in food, rest, recreation, healthy environment, herbal remedies and the most important is Buddhism practices In medication, seeking knowledge have greatly raised the quality of life for HIV and AIDS patients. Isan customs have given patients a conscience, tolerance to continue their fight and find a way to cure their illness and continue their life in happiness. ? Medwell Journals, 2009.